All the time.
I trigger loops in Ableton, sometimes sending one 'note on' with a 'foot on', and another 'note on' message with a 'foot off'. This allows me to trigger 2 different sounds on the same button.
In other situations, I will play full chords (3-4 note ons) through Ableton instruments. Since I use a single Ableton track to manage all instruments in a rack, I sometimes need to send CC from the SoftStep with the chord to have Ableton move to the proper Chain Selection.
To the same button, I then might add several lines of CC to control our lighting rig (DMXis)
And then, I might also use some additional modlines to control LED feedback displays on the SoftStep.
So, very rarely do I use a single modline per button.